PROVEN THERAPY:
Bone marrow cells have been used to treat over 1,000,000 patients over the last 50 years.
Standard of care for over 30 diseases, including:
Leukemias
Multiple Myeloma
Immune deficiency disorders
Aplastic anemia
Spinal fusions
Lymphomas
Non-union fractures
Osteonecrosis
Soft-tissue and joint pathology
APPLICATIONS
Use as a curative therapy for these diseases
Over 30,000 transplants per year.
Growth opportunity to save personal stem cells for future use.
Source of foundational cell lines with high regenerative capacity and decreased GvHD risk:
OBTAINING BONE MARROW CELLS
There are three critical elements to bone marrow derived therapies:
1) Harvesting of bone marrow
2) Processing to concentrate and often select cell populations and
3) Delivery of cells to the target tissue
While cell processing technologies have evolved, current harvest technologies have not. The latter are laborious and inefficient, requiring multiple punctures and small volume aspirates from the patient’s ileac crest (hip). This often requires general anesthesia and results in marrow that is diluted with blood and contains a low concentration of stem and progenitor cells.
There is a need for rapid, effective, and minimally invasive means of acquiring marrow derived cells, the key upstream step in many regenerative therapies, which can often be performed at the point of care.
Over 1,600 stem cell related clinical trials involving bone marrow derived stem cells are ongoing globally
Studies have shown that increased stem cell harvest improved clinical outcomes for both established and new regenerative cell-based therapies
1. Zimmer et al. Short and long-term outcomes of intracoronary and endogenously mobilized bone marrow stem cells in the treatment of ST-segment elevation myocardial infarction: a meta-analysis of randomized control trials. European Journal of Heart Failure. 2012 Jan;14(1):91-105.
2. Quyyumi et al. CD34(+) cell infusion after ST elevation myocardial infarction is associated with improved perfusion and is dose dependent. Am Heart J.2011 Jan;161(1)
Companies utilizing bone marrow derived stem cells in clinical trials:
Cell Types Found in Bone Marrow:
Hematopoietic stem cells (HSCs)
Mesenchymal Stem Cells (MSCs)
Endothelial Progenitor Cells (EPCs)
Bone Progenitor Cells